Record Display for the EPA National Library Catalog

RECORD NUMBER: 28 OF 30

Main Title Studies on the Percutaneous Absorption of Parathion and Paraoxon. V. Rate of Absorption of Paraoxon.
Author Fredriksson., Torsten ;
CORP Author Communicable Disease Center, Atlanta, Ga.
Year Published 1961
Stock Number PB-280 010
Additional Subjects Pesticides ; Insecticides ; Toxicology ; Enzymes ; Cholinesterase inhibitors ; Dosage ; Responses ; Parenteral infusions ; Absorption(Biology) ; Skin(Anatomy) ; Cats ; Bioassay ; Laboratory animals ; Reprints ; Phosphoric acid/(diethyl-ester)-(nitrophenyl-ester)
Holdings
Library Call Number Additional Info Location Last
Modified		 Checkout
Status
NTIS  PB-280 010 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 4p
Abstract
The rate of percutaneous absorption of paraoxon (E 600, or diethyl 4-nitrophenyl phosphate) has been determined by dose-response comparison following this mode of administration and intravenous infusion in the cat. The rate of inhibition of plasma cholinesterase activity was chosen as the parameter. Under the conditions of the study, the rate of percutaneous absorption was found to be constant in a given skin. By extrapolation from the activity curves, it was possible to determine the time required for paraoxon to diffuse from the topical deposit to the blood stream. This latency period was found to be approximately 12 minutes.