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Main Title Comparison of the Tumorigenic Response of SENCAR and C57BL/6 Mice to Benzo(a)pyrene and the Interexperimental Variability Over a Three-Year Period.
Author Nesnow, S. ; Bergman, H. ; Slaga, T. J. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Texas Univ. System Cancer Center, Smithville.
Year Published 1986
Report Number EPA/600/J-86/287;
Stock Number PB87-175071
Additional Subjects Mice ; Skin cancer ; Aromatic hydrocarbons ; Laboratory animals ; Toxicology ; Reprints ; Benzopyrene ; Tumor promoters ; Papilloma ; Tumor initiators ; C57BL/6 mice ; SENCAR mice ; TPA(12-O-tetradecanoylphorbol-13-acetate)
Library Call Number Additional Info Location Last
NTIS  PB87-175071 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 9p
SENCAR and C57BL/6 mice were compared for their ability to produce tumors after benzo(a)pyrene (B(a)P) initiation and 12-O-tetradecanoylphorbol-13-acetate (TPA) promotion. SENCAR mice initiated with 101 micrograms/mouse B(a)P and promoted with TPA (2 micrograms/mouse, twice weekly) produced large numbers of papillomas, whereas C57BL/6 mice produced none after 26 weeks of promotion. Continued treatment of the B(a)P-initiated C57BL/6 mice with TPA up to 52 weeks did not induce any papillomas nor did higher doses of B(a)P. Application of increased doses of TPA (10 micrograms/mouse, twice weekly) to B(a)P-initialed C57BL/6 mice (404 micrograms/mouse) for 50 weeks produced few papillomas. Substantial papilloma formation in C57BL/6 mice was observed after weekly treatment with B(a)P (101 micrograms/mouse), with maximal production occurring at weeks 39 to 41 of treatment. In contrast, SENCAR mice treated according to the same protocol produced an equivalent response with maximal papilloma formation occurring 12 to 13 weeks earlier. Therefore, C57BL/6 mice exposed to B(a)P are capable of producing papillomas under certain experimental conditions. (Copyright (c) 1986 Environmental Health Perspectives.)