||Pharmakon Research International, Inc., Waverly, PA. ;A.T. and T. Bell Labs., Murray Hill, NJ.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
In an 8.0 ml/kg Limit Test, ten rabbits (five males and five females) were dermally administered Pd Replenisher, Lot No. 1-3R'. Signs observed during the study include decreased activity, decreased muscle tone, abnormal gait, abnormal stance and prostration. A yellow-brown discoloration, slight to moderate erythema and necrosis of the skin at application site were observed during the course of the study. Three of ten rabbits died during the study. Necropsy findings on these animals revealed multiple black lesions throughout the stomach, pale or discolored intestines and discolored cecums with multiple lesions. No visible lesions were observed in any of the remaining animals upon terminal necropsy. Based upon the observations made in the Acute Exposure Dermal Toxicity Study in Rabbits, the estimated dermal LD(sub 50) for Pd Replenishner, Lot No. 1-3R' was determined to be greater than 8.0 ml/kg.