Record Display for the EPA National Library Catalog


Main Title Comparative methylation chemistry of platinum, palladium, lead, and manganese /
Author Taylor, Robert Thomas,
CORP Author California Univ., Livermore. Lawrence Livermore Lab.;Health Effects Research Lab., Research Triangle Park, N.C.
Publisher U.S. Environmental Protection Agency, Office of Research and Development, Health Effects Research Laboratory ; Available from the National Technical Information Service,
Year Published 1976
Report Number EPA/600-1-76-016
Stock Number PB-251 553
OCLC Number 02668830
Additional Subjects Methylation ; Platinum ; Palladium ; Lead(Metal) ; Manganese ; Air pollution ; Fuel additives ; Exhaust emissions ; Concentration(Composition) ; Toxicity ; Tissue extracts ; Biochemistry ; Air pollution effects(Plants) ; Air pollution effects(Humans) ; Cobalamin/methyl
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
EJBD ARCHIVE EPA 600-1-76-016 Headquarters Library/Washington,DC 01/27/2014
EJBD  EPA 600-1-76-016 c.1 Headquarters Library/Washington,DC 02/27/2014
EKBD  EPA-600/1-76-016 Research Triangle Park Library/RTP, NC 06/06/2003
ELBD  EPA 600-1-76-016 AWBERC Library/Cincinnati,OH 08/26/2016
NTIS  PB-251 553 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation vii, 26 pages : illustrations ; 27 cm.
A study was carried out to evaluate the potential for platinum, palladium, lead, and manganese salts and oxides to be biochemically methylated. Methylation is an important, well recognized, determinant of metal toxicity; the striking example being the extreme health hazard of methylated mercury. The possible biological methylation of the metals which are associated with emissions arising from the use of automotive fuels, fuel additives, and catalytic control devices is of special concern to the Environmental Protection Agency's Catalyst Research Program. Salts of platinum, palladium, and lead, and oxides of lead all containing the metal in a +4 valence were observed to demethylate methylcobalamin, a biologically active form of vitamin B-12. Inorganic salts and oxides of manganese were unreactive. No evidence for a stable monomethyl-metal derivative was found using palladium and lead compounds as reactants. However, salts of platinum +4 do result in the formation of stable methylation products. The reaction product formed from methylcobalamin and hexachloroplatinate was shown definitively to be a monomethyl-platinum compound. It is sufficiently stable in aqueous solutions under a variety of conditions to exist in freshwater ecosystems and to exhibit toxic effects on mammalian cells.
"EPA/600-1-76-016." "March 1976."