| Main Title |
Response to issues and data submissions on the carcinogenicity of tetrachloroethylene (perchloroethylene) / |
| Author |
Parker, J. C.
|
| CORP Author |
Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment. |
| Publisher |
U.S. Environmental Protection Agency, Center for Environmental Research Information, |
| Year Published |
1991 |
| Report Number |
EPA/600/6-91/002F; OHEA-C-378; PB95221958 |
| Stock Number |
PB95-221958 |
| OCLC Number |
32655395 |
| Subjects |
Carcinogens ;
Tetrachloroethylene--Health effects ;
Perchloroethylene--Health effects
|
| Additional Subjects |
Toxicity ;
Carcinogenesis ;
Tetrachloroethylene ;
Halohydrocarbons ;
Malignant neoplasms ;
Rats ;
Mice ;
Metabolism ;
Mutagenicity ;
Bioassay ;
Risk assessment ;
Genetics ;
Health hazards ;
PCE ;
Perchloroethylene ;
Perc
|
| Internet Access |
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| EHAM |
EPA/600/6-91/002F |
|
Region 1 Library/Boston,MA |
05/25/2016 |
| EJED |
EPA 600/6-91-002F |
|
OCSPP Chemical Library/Washington,DC |
07/16/1999 |
| EKBD |
EPA-600/6-91-002F |
|
Research Triangle Park Library/RTP, NC |
06/23/1995 |
| EKCD |
EPA/600/6-91/002F |
|
CEMM/GEMMD Library/Gulf Breeze,FL |
08/21/2018 |
| ELBD ARCHIVE |
EPA 600-6-91-002F |
Received from HQ |
AWBERC Library/Cincinnati,OH |
10/04/2023 |
DISPERSAL |
| EMBD |
EPA/600/6-91/002F |
|
NRMRL/GWERD Library/Ada,OK |
01/11/2002 |
| ERAD |
EPA 600/6-91-002F |
|
Region 9 Library/San Francisco,CA |
08/04/1995 |
| ESAD |
EPA 600-6-91-002F |
|
Region 10 Library/Seattle,WA |
10/10/2017 |
| NTIS |
PB95-221958 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
vii, 73 pages : illustrations ; 28 cm |
| Abstract |
The scientific debate over the potential carciongenicity of tetrachloroethylene (perchloroethylene, perc, PCE) spans several years. The document reviews the issues considered by the EPA's Science Advisory Board (SAB) during its review of the Draft Addenedum to the Health Assessment Document for Tetrachloroethylene (1986) and discusses relevant research data published between 1986 and early 1991. The topics include three tumor end points observed in rodents: (1) hepatocellular carcinoma in male and female mice, (2) renal tubule neoplasia in male rats, and (3) mononuclear cell leukemia in male and female rats, and data on metabolism, metagenicity, peroxisome proliferation, and alpha-2u-globulin. EPA's recommended weight-of-evidence classification of perc is B2, probable human carcinogen. |
| Notes |
"Office of Research and Development"--Cover. "Office of Health and Environmental Assessment." "September 1991." "EPA/600/6-91/002F." Includes bibliographical references. |
