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Main Title Acute Oral Toxicity in Rats with P-tert-butyl Benzoic Acid with Cover Letter dated 08/21/1986.
CORP Author Hazleton Labs. America, Inc., Madison, WI.; Proctor and Gamble Co., Cincinnati, OH. Ivorydale Technical Center.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1986
Report Number 86860000121
Stock Number OTS0510266
Additional Subjects Toxicology ; Health effects ; P-(tert-butyl)benzoic Acid (98-73-7) ; Acute Toxicity ; Mammals ; Rats ; Oral ; Gavage ; Toxic substances ; Laboratory animals ; CAS No 98-73-7
Library Call Number Additional Info Location Last
NTIS  OTS0510266 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 148p
Acute oral toxicity was evaluated in groups of 10 male Sprague-Dawley albino rats administered single doses of p-tert-butyl benzoic acid by oral gavage at levels of 0.72 g/kg body weight in NaOH/HCl (pH 8.0) (group A), or 0.70 g/kg body weight in acetone/DMSO (group B). Mortality was observed in 2 animals in group A, and in 7 animals in group B. Clinical observations in group A included hypoactivity, ataxia, bradypnea, yellow-stained abdomen, and impaired use of front limbs. Clinical observations in group B included hypoactivity, ataxia, bradypnea, no pain reflex, possible respiratory congestion, prostration, yellow-stained anal area, lacrimation, and hypothermia. A significant decrease in mean and relative testes weight (analysis of variance, p < 0.05) was observed in one animal in both group A and group B. Gross necropsy revealed bilateral small testes in both of these animals, while other treatment related effects in decedents or survivors sacrificed at 14 days were not observed by the investigators. Histopathological examination revealed hypospermatogenesis in all of the rats sacrificed in either group, as evidenced by fewer (but normal) spermatogenic cells in the seminiferous tubules.