| Main Title |
Does Iron or Heme Control Rat Hepatic Delta-Aminolevulinic Acid Synthetase Activity. |
| Author |
Kitchin, Kirk T. ;
Farmer, Jackie ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
| Year Published |
1981 |
| Report Number |
EPA-600/J-81-331; |
| Stock Number |
PB82-249277 |
| Additional Subjects |
Iron ;
Rats ;
Laboratory animals ;
Nitrogen organic compounds ;
Acetamide/allyl-isopropyl ;
Ethylene diamine/sodium-tetraacetate ;
Levulinic acid synthetase/amino ;
Oxygenases
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB82-249277 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
9p |
| Abstract |
Disodium ethylenediamine tetraacetic acid and/or allylisopropylacetamide administration to rat pups did not evoke a premature induction of hepatic d-aminolevulinic acid synthetase. Administration of iron to adult rats did not alter d-aminolevulinic acid synthetase activity and had little inductive effect on home oxygenase activity. Both heme and cobalt/dextran rapidly induced microsomal heme oxygenase by 3-8 fold. Induction of heme oxygenase by heme could be totally blocked by concurrent administration of cyclo-heximide. These results argue against the hypothesis that iron is the physiological mediator of d-aminolevulinic acid synthetase activity. |
