Record Display for the EPA National Library Catalog


Main Title Effect of 'In vivo' Ozone Exposure to Dorset Sheep, an Animal Model with Low Levels of Erythrocyte Glucose-6-Phosphate Dehydrogenase Activity.
Author Moore, Gary S. ; Calabrese, Edward J. ; Schulz, Elizabeth ;
CORP Author Massachusetts Univ., Amherst. Dept. of Public Health.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1981
Report Number EPA-R-805797-01; EPA-600/J-81-594;
Stock Number PB83-129932
Additional Subjects Ozone ; Toxicology ; Exposure ; In vivo analysis ; Sheep ; Laboratory animals ; Chromosome abnormalities ; Reprints ; Oxidoreductases ; Animal models ; Air pollution effects(Animals)
Library Call Number Additional Info Location Last
NTIS  PB83-129932 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 10p
Considerable interest has recently been directed to the possible extrapulmonary effects caused by exposure to ambient ozone. Studies have now demonstrated that ozone exposure may result in chromosomal aberrations in circulating lymphocytes of Chinese hamsters, altered drug metabolism in mice, as well as biochemical changes in red blood cell metabolism in several animal models and humans. As a result of ozone induced in vivo alteration of red cell function within human subjects, Calabrese et al. (1977) hypothesized that individuals with an erythrocyte glucose-6-phosphate dehydrogenase (G-6-PD) deficiency would be at increased hemolytic risk to elevated ambient ozone exposure.