Record Display for the EPA National Library Catalog

RECORD NUMBER: 5 OF 30

OLS Field Name OLS Field Data
Main Title Chromosome Aberration Assay in the Chinese Hamster Ovary (CHO) Cells with Test Article Sodium Dimethyldithiocarbamate with Cover Letter dated 01/17/86.
CORP Author Microbiological Associates, Bethesda, MD.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Publisher Jan 1986
Year Published 1986
Report Number FYI-OTS-0186-0476;
Stock Number OTS-0000476-0
Additional Subjects Pesticides ; Environmental health ; Public health ; Assays ; Chromosome aberration assay ; Chinese hampster ovary cells ; Sodium dimethyldithiocarbamatewith
Holdings
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Status
NTIS  OTS-0000476-0 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 10/08/2007
Collation 101p
Abstract
The text article, Sodium dimethyldithiocarbamate, was tested in the chromosome aberration assay using Chinese hamster ovary cells. The assay was conducted both in the absence and presence of an Aroclor-induced S-9 activation system at dose levels of 3, 1, 0.3, 0.1 nl/ml and 20, 10, 3, 1 nl/ml. respectively. A delayed harvest was also carried out at 3 and 1 nl/ml in the absence of S-9 and at 20 nl/ml in the presence of S-9 because of cell cycle delay at this dose level. A statistically significant increase in structural chromosome aberrations was observed at the highest dose tested in the presence of S-9. No increase was observed in the nonactivated study. Sodium dimethylidithiocarbamate was conducted to be suspect in the CHO chromosome aberration assay in the presence of S-9 and negative in the absence of S-9.