Record Display for the EPA National Library Catalog


Main Title Toxicity of Metepa to Rats, With Notes on Two Other Chemosterilants.
Author Gaines, Thomas B. ; Kimbrough., Renate D. ;
CORP Author Communicable Disease Center, Atlanta, Ga.
Year Published 1964
Stock Number PB-280 837
Additional Subjects Toxicology ; Laboratory animals ; Bioassay ; Ingestion(Biology) ; Rats ; Skin(Anatomy) ; Experimental data ; Dosage ; Reproductive system ; Testis ; Ovary ; Bone marrow ; Sterility ; Histology ; Males ; Fertility ; Phosphorus organic compounds ; Reprints ; Chemosterilants ; Toxic substances ; Tepa ; Metepa ; Apholate ; Phosphine oxide/tris(aziridinyl) ; Phosphine oxide/tris(methyl-aziridinyl)
Library Call Number Additional Info Location Last
NTIS  PB-280 837 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 9p
Although tepa, metepa, and apholate are only moderately toxic to rats by the oral route, the dermal toxicity of the first two is relatively high as compared with that of conventional insecticides. In the experiments reported, metepa caused no damage to he intestinal epithelium of rats, except following single doses in the fatal range. The organ primarily affected by repeated small doses of metepa is the testis; the ovaries and bone marrow are damaged only by higher dosage levels. Metepa at an oral dosage of 5 mg/kg/day (about 4% of the acute oral LD50 level daily) produced severe reduction of fertility of male rats within 22 days, sterility within 70 days, and testicular atrophy within 77 days. Half that dosage produced a smaller reduction in fertility and only partial testicular atrophy in some rats within 197 days. Dosages of 1.25 mg/kg/day or less produced no detectable effect on fertility and no histological change in the testis in 197 days. The survival of newborn rats was not affected by any dosage given to their sires.