||Possible Animal Models of Follicular Development Relevant to Reproductive Toxicology.
Greenwald, G. S. ;
||Kansas Univ. Medical Center, Kansas City.;Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment.
||EPA/600/J-87/474 ; OHEA-R-250
Laboratory animals ;
Reproductive system ;
Estrous cycle ;
||Some EPA libraries have a fiche copy filed under the call number shown.
Models of follicular development in rodents that may be applicable to reproductive toxicology are considered. The value of evaluating changes in follicular numbers during the estrous cycle is stressed. Most of the methods involve in vivo manipulations. However, the use of enzymes to dissociate intact follicles from the ovary and their subsequent in vitro development in the presence or absence of xenobiotics offers an alternative, attractive approach. (Copyright (c) 1987 Pergamon Journals Ltd.)