Record Display for the EPA National Library Catalog


Main Title Gonadal Effects of Fetal Exposure to the Azo Dye Congo Red in Mice: Infertility in Female but Not Male Offspring.
Author Gray, L. E. ; Ostby, J. S. ; Kavlock, R. J. ; Marshall, R. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Reproductive Toxicology Branch. ;ManTech Environmental Technology, Inc., Research Triangle Park, NC.
Publisher c1992
Year Published 1992
Report Number EPA/600/J-93/119;
Stock Number PB93-181071
Additional Subjects Congo red ; Toxicity ; Male infertility ; Testis ; Ovary ; Dose-response relationships ; Seminiferous tubules ; Litter size ; Organ weight ; Graafian follicles ; Reprints ;
Library Call Number Additional Info Location Last
NTIS  PB93-181071 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 14p
The study describes the relationship between gonadal agenesis and fertility in male and female mice exposed in utero to the diazo dye Congo red (CR). Maternal CR treatment inhibited testicular and ovarian function in the offspring after oral administration of 1 or 0.5 g/kg/day on Gestational Days 8-12. The testes of male offspring from CR-exposed dams were small in size and contained hypospermatogenic seminiferous tubules. However, despite the fact that testis weight was reduced by more than 70% in some males, they displayed normal levels of fertility when mated to untreated females for over 10 months. In contrast, female offspring from CR-exposed dams produced only about half as many litters and pups as the control pairs did under long-term mating conditions. In summary, prenatal exposure to the dye CR affects the gonads of both male and female offspring, but only the female offspring display reduced fertility.