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Main Title Comparison of Enhancement of GGTase-Positive Foci and Induction of Ornithine Decarboxylase in Rat Liver by Barbiturates.
Author Pereira, Michael A. ; Savage, Jr.,, Russell E. ; Herren, Sydna L. ; Guion, Charles W. ;
CORP Author Health Effects Research Lab., Cincinnati, OH.
Year Published 1981
Report Number EPA-600/J-82-271;
Stock Number PB83-157586
Additional Subjects Barbiturates ; Rats ; Liver ; Malignant neoplasms ; Comparison ; Reprints ; Cancer ; GGTase ; Ornithine decarboxylase ; Carcinogenesis
Library Call Number Additional Info Location Last
NTIS  PB83-157586 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 6p
The induction of ornithine decarboxylase (ODC) by barbiturates and the ability of barbiturates to enhance neoplastic progression of chemically initiated cancer was examined in rat liver. All seven barbiturates induced ODC with barbital (7.7 fold increase) and phenobarbital (5.7 fold increase) demonstrating the most potent activity. Maximum induction of ODC by phenobarbital was obtained in 18 h. Barbital (500-5000 p.p.m.) and phenobarbital (500 p.p.m.) administered in the drinking water enhanced the appearnace of diethylnitrosamine (DENA)-initiated gamma-glutamyltranspeptidase (GGTase)-positive foci. Amobarbital, hexabarbital and pentabarbital did not enhance the appearance of GGTase-positive foci. In the absence of previous initiation by DENA, the enhancing regimen of the barbiturates did not cause the appearance of GGTase-positive foci. Barbiturates induced ODC activity in rat liver and enhanced the incidence of DENA initiated GGTase-positive foci.