| Main Title |
Muscarinic Cholinergic Receptor Regulation and Acetylcholinesterase Inhibition in Response to Insecticide Exposure during Development. |
| Author |
Dvergsten, C. ;
Meeker, R. B. ;
|
| CORP Author |
North Carolina Univ. at Chapel Hill. Dept. of Neurology.;Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div. |
| Publisher |
cJul 94 |
| Year Published |
1994 |
| Report Number |
EPA/600/J-94/515; |
| Stock Number |
PB95-148771 |
| Additional Subjects |
Parathion ;
Acetylcholine ;
Muscarinic regulators ;
Rats ;
Cholinesterase inhibitors ;
Brain ;
Dose-response relationships ;
Developmental biology ;
Enzymes ;
Thiophosphoric acid esters ;
Exposure ;
Receptor sites(Physiology) ;
Hippocampus ;
Cerebral cortex ;
Reprints ;
Parathion ;
Organophosphorous pesticides
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB95-148771 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
15p |
| Abstract |
Daily injections of low doses of the organophosphorus pesticide, parathion, into neonatal rats during the rapid phase of cholinergic system development (postnatal days 8-20), resulted in an average 67% inhibition of acetylcholinesterase and a 23% down regulation of muscarinic cholinergic receptors on postnatal day 21. A correlation of 0.78 was found between the level of acetylcholinesterase inhibition and the decrease of muscarinic receptors. Regional analyses of receptor autoradiograms indicated that muscarinic receptors in the cortex and hippocampus were most sensitive to the effects of acetylcholinesterase inhibition. The anterior thalamus was notable in having a high density of cholinertic receptors which were relatively unaffected by parathion treatment. |
