Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Short-Term Clinical and Neuropathologic Effects of Cholinesterase Inhibitors in Rats.
Author Ehrich, M. ; Shell, L. ; Rozum, M. ; Jortner, B. S. ;
CORP Author Virginia-Maryland Regional Coll. of Veterinary Medicine, Blacksburg, VA. ;Virginia Polytechnic Inst. and State Univ., Blacksburg. Dept. of Statistics.;Health Effects Research Lab., Research Triangle Park, NC.
Publisher c1993
Year Published 1993
Report Number EPA-68D80098; EPA/600/J-94/397;
Stock Number PB95-126462
Additional Subjects Cholinesterase inhibitors ; Nervous system ; Pathology ; Organophosphate insecticides ; Reprints ; Rats ; Dose-response relationships ; Tables(Data) ; Myelin sheath ; Functional observation battery
Library Call Number Additional Info Location Last
NTIS  PB95-126462 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 03/06/1995
Collation 18p
Adult male Long Evans rats were given a single administration of 3 dosage levels of the organophosphorus compounds tri-ortho-tolyl phosphate (TOTP), diisopropyl fluorophosphate (DFP), phenyl saligenin phosphate (PSP), mipafox, malathion, and dichlorvos or the carbamate carbaryl. Acetylcholinesterase and neurotoxic esterase activities were inhibited in a dose-dependent manner, with the highest dosages of all these compounds inhibiting activities of these enzymes in brain by at least 37% and 64%, respectively, at 4 and 48 hours after administration. Rats given the high doses of TOTP (1000 mg/kg), DFP (3 mg/kg), malathion (2000 mg/kg), and carbaryl (160 mg/kg) weighed significantly less than control rats 14 days after administration. A functional observational battery (FOB) was used to screen for neurotoxic effects 1, 2, and 3 weeks after exposure. All 7 test compounds were capable of causing changes in parameters indicative of behavioral and central nervous system excitability. In addition, dose-related alterations in response to approach were seen in rats given DFP, malathion, dichlorvos, and carbaryl.