| Main Title |
Toxaphene composition and toxicology / |
| Author |
Casida, John E., ;
Casida, John E., 1929-
|
| Other Authors |
|
| Publisher |
U.S. Environmental Protection Agency, Office of Research and Development, Health Effects Research Laboratory, |
| Year Published |
1978 |
| Report Number |
EPA-600/1-78-060; PB-288 412; EPA-R-803913 |
| Stock Number |
PB 288 412 |
| OCLC Number |
21069166 |
| Subjects |
Insecticides--toxicity ;
Insecticides--analysis ;
Insecticides, Organochlorine--toxicity ;
Insecticides, Organochlorine--analysis
|
| Additional Subjects |
Insecticides ;
Pesticides ;
Toxicology ;
Chemical analysis ;
Chlorine organic compounds ;
Metabolism ;
Mutations ;
Tables(Data) ;
Salmonella typhimurium ;
Laboratory animals ;
Experimental data ;
Samples ;
Gas chromatography ;
Pest control ;
Insect control ;
Toxaphene ;
Camphenes ;
Procedures ;
Thin layer chromatography
|
| Internet Access |
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| EJBD |
EPA 600-1-78-060 |
|
Headquarters Library/Washington,DC |
04/22/2014 |
| EKBD |
EPA-600/1-78-060 |
|
Research Triangle Park Library/RTP, NC |
09/07/2001 |
| ELBD ARCHIVE |
EPA 600-1-78-060 |
Received from HQ |
AWBERC Library/Cincinnati,OH |
10/04/2023 |
| ELBD |
EPA 600-1-78-060 |
|
AWBERC Library/Cincinnati,OH |
07/20/2022 |
| NTIS |
PB-288 412 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
xiii, 52 pages : illustrations |
| Abstract |
The composition and metabolism of Toxaphene have been examined to aid in understanding the conditions under which this insecticide can be most effectively and safely used. Each of 8 Toxaphene samples manufactured by Hercules Chemical Co. from 1949 to 1975 shows the same 29 major peaks and in almost identical ratios. About 85% of the total peak area is accounted for by these 29 peaks which individually vary from 1 to 8% of the total. The 8 Toxaphene samples were easily differentiated from 12 samples of chlorinated terpenes from other manufacturers in the United States and abroad. There is surprisingly little variation in the acute toxicity of any sample. Fat from chickens and mammals treated orally with Toxaphene contains products similar in GLC characteristics to Toxaphene itself whereas liver and feces contain Toxaphene-derived products of greatly altered GLC properties. Toxaphene preparations and related chlorinated terpenes are mutagens in the histidine-requiring Salmonella typhimurium assay. The most potent mutagenic components, which are not identified, reside in the polar fractions on crystallization or column chromatography. |
| Notes |
"EPA-600/1-78-060." "Grant No. R-803913." |
