Record Display for the EPA National Library Catalog
RECORD NUMBER: 393 OF 1413| Main Title | Initial Submission: Letter Containing a Summary of a Teratology Study in Rats on Propazine (Full Report Previously Submitted to US EPA under Fifra: 073885). | |||||||||||
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| CORP Author | CIBA-GEIGY Corp., Toms River, NJ.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. | |||||||||||
| Year Published | 1992 | |||||||||||
| Report Number | 88-920000789 | |||||||||||
| Stock Number | OTS0535300 | |||||||||||
| Additional Subjects | Toxicology ; Health effects ; Propazine ; Reproduction/fertility Effects ; Teratogenicity ; Mammals ; Rats ; Oral ; Gavage ; Toxic substances ; Laboratory animals ; CAS No 139-40-2 | |||||||||||
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| Collation | 5p | |||||||||||
| Abstract | Propazine (CAS No. 139-40-2) was evaluated for developmental toxicity. It was administered in pregnant albino rats (number/group not reported) dosed with 0, 10, 100, or 500 mg/kg/day of body weight by oral gavage. Signs of toxicity included reduced body weight gains and food consumption and an increase in the incidence of clinical signs. At 500 mg/kg/day of body weight, fetal weights were reduced and an increased incidence of incompletely ossified cranial structures was reported. This study was briefly summarized and no further information was reported. |