Record Display for the EPA National Library Catalog

RECORD NUMBER: 1405 OF 1413

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Main Title

US EPA Submission Summary Report: Carbamic Acid Nitrile (Sanitized).

CORP Author

; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.

Year Published

2000

Report Number

8EHQ-0490-0952S

Stock Number

OTS0524054-3

Additional Subjects

Toxicology ; Health effects ; Carbamic Acid Nitrile ; Chronic Toxicity ; Carcinogenicity ; Mammals ; Mice ; Oral ; Diet ; Toxic substances ; Laboratory animals ; CAS No 420-04-2

Holdings

Library	Call Number	Additional Info	Location	Last Modified	Checkout Status
NTIS	OTS0524054-3	Some EPA libraries have a fiche copy filed under the call number shown.		07/26/2022

Collation

Abstract

Cyanamide (CAS No. 420-04-2) was evaluated for carcinogenicity. The test substance was administered in the drinking water of male and female Crl:CD-1(ICR)-BR mice (60/sex/group) at dose levels of 0, 70, 200, or 600 ppm for 100 weeks (males) and 104 weeks (females). Preliminary findings reported 8 cases of benign granulosa-theca tumors of the ovary in females at the 600 ppm dose level. In the control group, 2 similar tumors were also found. Pathological findings indicated five instances of ovarian hyperplastic lesions.

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