Record Display for the EPA National Library Catalog


Main Title Evaluation of Delayed Neurotoxicity and Dose-Response Relationships of Phosphate Esters in the Adult Hen Prepared by Monsanto Company with Cover Letter.
CORP Author Du Pont de Nemours (E.I.) and Co., Wilmington, DE. DuPont Environmental Remediation Services.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Publisher 4 Feb 1983
Year Published 1983
Report Number 878211730;
Stock Number OTS-0205858
Additional Subjects Toxicity ; Phosphates ; Esters ; Neurotoxins ; Dose response relationships ; Alkyls ; Phenols ; Histological techniques ; Tritration ; Oral intake ; Dermal absorption ; Evaluation ; Laboratory animals ; Aryl phosphates ; Phosphoric acid ; Methylphenyl ester
Library Call Number Additional Info Location Last
NTIS  OTS-0205858 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 25p
An oral multiple-dose technique in hens was developed to determine the neurotoxic potential of a series of triaryl-, trialkyl- and alkyl-aryl phosphates. This potential was estimated by observation of abnormal behavioral signs and always verified by histological examination. This procedure permits dose tritration of an active material to quantify dose-response relationships. Initial evaluation of a series of phosphates for neurotoxicity yielded 3 active materials: tricresyl-phosphate, cresyl-diphenyl phosphate and o-isopropylphenyl- diphenyl-phosphate. Subsequent titration of active materials demonstrated that their neurotoxic potential differed markedly.