Record Display for the EPA National Library Catalog

RECORD NUMBER: 320 OF 564

Main Title Micronucleus Cytogenetic Assay in Mice, with Cover Letter dated 10/26/95. Final Report.
CORP Author Microbiological Associates, Bethesda, MD.; Elf Atochem North America, Philadelphia, PA.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1995
Report Number 86960000057
Stock Number OTS0558197
Additional Subjects Toxicology ; Health effects ; Di-n-butylamine (111-92-2) ; Genotoxicity ; Chromosomal Effects ; Mammals ; Mice ; Oral ; Gavage ; Toxic substances ; Laboratory animals ; CAS No 111-92-2
Holdings
Library Call Number Additional Info Location Last
Modified		 Checkout
Status
NTIS  OTS0558197 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 32p
Abstract
The clastogenic potential of di-n- butylamine (CAS No. 111-92-2) was evaluated by incidence of micronucleated polychromatic erythrocytes in bone marrow of Harlan Sprague-Dawley ICR mice (20/sex/group) administered single oral gavage doses at 55, 110, or 220 mg/kg bodyweight. Mortality occurred among high-dose males (3/20) and females (1/20), and lethargy was observed in both males and females of all treatment groups. While treated mice exhibited slight reductions in polychromatic erythrocytes to erythrocyte ratios (up to 19%) relative to vehicle control (corn oil) animals, there was no significant increase in micronucleated polychromatic erythrocytes at 24, 48 or 72-hour post-treatment examination in either male or female treated mice when compared to controls.