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Main Title Myelin Basic Protein-Messenger RNA (MBP-mRNA) Expression during Triethyltin-Induced Myelin Edema.
Author Veronesi, B. ; Jones, K. ; Gupta, S. ; Pringle, J. ; Mezei, C. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Environmental Toxicology Div. ;Dalhousie Univ., Halifax (Nova Scotia). Dept. of Biochemistry.
Publisher c1991
Year Published 1991
Report Number EPA/600/J-92/072;
Stock Number PB92-150861
Additional Subjects Encephalitogenic basic proteins ; Messenger RNA ; Gene expression ; Edema ; Trimethyltin compounds ; Toxicity ; Rats ; Brain ; Nucleic acid hybridization ; Northern blotting ; Electron microscopy ; DNA probes ; Optic nerve ; Reprints ;
Library Call Number Additional Info Location Last
NTIS  PB92-150861 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 14p
Triethyltin (TET) is a neurotoxicant that produces severe but transient cerebral edema, characterized ultrastructurally by vacuolation of the intraperiod line of central nervous system (CNS) myelin. In the present study, the genomic expression (i.e., mRNA) of MBP was monitored throughout the pathogenesis of TET-induced myelin edema and recovery in Sprague-Dawley rats given a single injection of a neuropathic (8.0 mg/kg) or non-neuropathic (0.8 mg/kg) dose of TET-bromide. Levels of MBP-mRNA from the anterior and posterior brain were collected 1 hr, 3 hr, 2d, and 7d, postexposure. The optic nerve andd caudal brainstem, representing anterior and posterior brain sites, respectively, were examined at the same time-points for ultrastructural evidence of edema and recovery. Study data indicate that neuropathic doses (8.0 mg/kg) of TET significantly stimulated MBP transcript throughout the brain at all exposure time-points. The magnitude and time-course of this stimulation differed in the anterior and posterior brain, with the latter region showing higher levels of MBP-mRNA.