Record Display for the EPA National Library Catalog


Main Title Morphometric and Electrophysiological Evidence for a Diameter-Based Rate of Degeneration in the Optic Nerve of the Rat (Journal Version).
Author Veronesi, B. ; Boyes, W. K. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Publisher 1988
Year Published 1988
Report Number EPA/600/J-88/152;
Stock Number PB89-110480
Additional Subjects Morphology ; Electrophysiology ; Optic nerve ; Laboratory animals ; Rats ; Deterioration ;
Library Call Number Additional Info Location Last
NTIS  PB89-110480 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 16p
The diameter-based rate of degeneration in the rat's optic nerve was examined using coordinated morphological and electrophysiological techniques. Long-Evans male rats were implanted with indwelling stimulating electrodes in the optic chiasm and recording electrodes in the stratum opticum of the superior colliculus. After one week, enucleation was performed on one optic nerve with the unoperated side serving as the control. In another set of identically treated rats, morphological analysis of the optic nerve over D-0-7 was performed. A linear regression analysis revealed an exponential rate of degeneration as a direct function of axonal diameter, that is the number of fibers.