Polyomavirus Life Cycle -- Transformation by Polyomaviruses -- Polyomaviruses and Disease -- The Life Cycle of Human Papillomaviruses -- Papillomavirus Transformation -- Papillomaviruses: Biology, Diversity, and Pathogenesis -- Adenovirus Transformation -- Overview of the Large DNA Tumor Viruses -- Epidemiology of EBV Infection -- EBV Diseases -- The Epstein-Barr Virus Genome -- Epstein-Barr Virus Transforming Proteins: Biologic Properties and Contribution to Oncogenesis -- The Epstein-Barr Virus Lytic Life Cycle -- Epstein-Barr Virus Latent Infection Nuclear Proteins: Genome Maintenance and Regulation of Lymphocyte Cell Growth and Survival -- Epstein-Barr Virus Entry -- EBV Immunotherapy -- KSHV Epidemiology and Subtype Evolution -- to Diseases Associated with Kaposi's Sarcoma-Associated Herpesvirus -- Organization and Expression of the Kaposi's Sarcoma-Associated Herpesvirus Genome -- KSHV Latent Genes and Their Regulation -- Regulation of Expression, Mode of Action and Downstream Targets of ORF50 Protein in KSHV Lytic Cycle Activation -- HHV-8/KSHV Proteins Involved in Signaling and Transformation -- KSHV Entry and Infection of Target Cells -- KSHV Immune Evasion -- Non-coding Regulatory RNAs of the DNA Tumor Viruses -- AIDS and Associated Malignancies -- Primate Models for Gammaherpesvirus-Associated Malignancies -- Murine Gammaherpesvirus 68 Infection of Mice: A Small Animal Model for Characterizing Basic Aspects of Gammaherpesvirus Pathogenesis. The DNA tumor viruses are central to many branches of molecular and cellular biology. This very diverse group of viruses attack common cellular pathways, which makes them powerful tools for understanding how multiple complex pathways are integrated. Additionally, the unique mechanisms employed by each viral system to alter cellular functions serve as powerful molecular probes for the identification of new targets and pathways. The scientific impact of the DNA tumor viruses extends far beyond their etiologic role in human cancers, or their contributions to our basic understanding of the cellular pathways that drive tumorigenesis. Currently, research on these viruses lies at the interface of cancer and the innate and adaptive immune response, investigating how infectious agents influence, evade, and utilize systems that regulate these processes. Thus, DNA tumor viruses serve as models for the systems biology of host-pathogen interactions. "DNA Tumor Viruses," edited by Blossom Damania and James M. Pipas, summarizes recent advances in our understanding of this diverse and fascinating collection of viruses.