Cancer Statistics: Some Facts -- Assessing the magnitude of the problem -- The problem is growing, not going away -- What Is Cancer? -- Cancer through the ages -- Our current understanding -- How Is Cancer Treated? -- The cancer cell-kill paradigm and its corollaries -- Chemotherapy drugs -- Treatment outcomes: Dismal by any standard -- Why Does This System Persist? -- The role of the National Cancer Institute -- Publications: The facts and nothing but the facts? -- From the doctors' perspective -- From the patients' perspective -- Where Do We Go From Here? -- A vision for the future -- Shifting from the cell-kill paradigm to pharmacogenomics. After reviewing the history of cancer and its impact on the population, Dr. Faguet exposes the antiquated notions that have driven cancer drug development, documents the stagnation in treatment outcomes despite major advances in cancer genomics and growing NCI budgets, and identifies the multiple factors that sustain the status quo. He shows that, contrary to frequent announcements of breakthroughs, our current cancer control model cannot eradicate most cancers and the reasons why. Significantly, this book also delineates a way forward via a shift from the discredited cell-kill approach of the past to an integrated, evidence-driven cancer control paradigm based on prevention, early diagnosis, and pharmacogenomics. The author's views are based on data published in mainstream scientific journals and other reliable references, 432 of which are cited.