Principles of Human Tumor Virology -- History of Papillomavirus Research -- Phylogeny and Typing of Papillomaviruses -- The Differentiation-Dependent Life Cycle of Human Papillomaviruses in Keratinocytes -- Papillomavirus Structure and Assembly -- Viral Entry and Receptors -- Human Papillomavirus Transcription -- DNA Replication of Papillomaviruses -- Papillomavirus E5 Proteins -- Human Papillomavirus E6 and E7 Oncogenes -- In Vivo Models for the Study of Animal and Human Papillomaviruses -- The Humoral Immune Response to Human Papillomavirus -- Cell-Mediated Immune Responses to Human Papillomavirus -- Papillomavirus Vaccines -- Clinical Assessment, Therapies, New Tests, and Algorithms -- Possible Worldwide Impact of Prevention of Human Papillomavirus Infection. The papillomaviruses have emerged as the best understood viruses that cause cancer in humans. This volume reviews the remarkable confluence of science, medicine, and public health that recently culminated in the approval of vaccines that prevent many human papillomavirus infections, the first vaccines specifically designed to prevent human cancer. Basic laboratory studies of viral DNA replication, gene expression, protein function, and virus-host interactions have provided fundamental insights into these important processes. Most importantly, human papillomavirus infection has been shown to be a crucial event in the development of several human cancers, most notably cervical cancer, a leading cause of cancer death in women. The Papillomaviruses is an ideal book for scientists, professionals, clinicians, and graduate students in the fields of immunology, infectious disease, virology, microbiology, cell biology, and cancer biology and research.