Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Effects of Repeated Whole Body Inhalation Exposure to Octamethylcyclotetasiloxane (D4) Vapors on Hepatic Microsomal CYP2B1/2 Induction in Rats, with Cover Letter dated 02/25/1999.
CORP Author Dow Corning Corp., Midland, MI.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1999
Stock Number OTS0573879
Additional Subjects Toxicology ; Health effects ; Octamethylcyclotetrasiloxane ; Chronic toxicity ; Cell transportation ; Mammals ; Rats ; Inhalation ; CAS No 556-67-2
Library Call Number Additional Info Location Last
NTIS  OTS0573879 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 09/09/2010
Collation 431p
Previous studies within Dow Corning have shown that repeated inhalation exposure to OctamethyIcyclotetrasiloxane (D4) produces reversible hepatomegaly and dose-dependent induction of hepatic microsomal CYP2B1/2 enzymes. Maximum induction of CYP2B1/2 was achieved between 5 and 7 days of exposure. However, a detailed dose-response curve for the induction of CYP2B1/2 has not been determined. Moreover, the amount of D4 in the liver, blood, and fat over a wide exposure range has not been shown. Therefore, the objective of this study was to provide a complete dose-response profile for the induction of CYP2B1/2 activity in rat hepatic microsomes that can be related to exposure concentration and tissue dose.