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RECORD NUMBER: 20 OF 69

OLS Field Name OLS Field Data
Main Title Effects of Repeated Whole Body Inhalation Exposure to Octamethylcyclotetasiloxane (D4) Vapors on Hepatic Microsomal CYP2B1/2 Induction in Rats, with Cover Letter dated 02/25/1999.
CORP Author Dow Corning Corp., Midland, MI.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1999
Stock Number OTS0573879
Additional Subjects Toxicology ; Health effects ; Octamethylcyclotetrasiloxane ; Chronic toxicity ; Cell transportation ; Mammals ; Rats ; Inhalation ; CAS No 556-67-2
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NTIS  OTS0573879 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 09/09/2010
Collation 431p
Abstract
Previous studies within Dow Corning have shown that repeated inhalation exposure to OctamethyIcyclotetrasiloxane (D4) produces reversible hepatomegaly and dose-dependent induction of hepatic microsomal CYP2B1/2 enzymes. Maximum induction of CYP2B1/2 was achieved between 5 and 7 days of exposure. However, a detailed dose-response curve for the induction of CYP2B1/2 has not been determined. Moreover, the amount of D4 in the liver, blood, and fat over a wide exposure range has not been shown. Therefore, the objective of this study was to provide a complete dose-response profile for the induction of CYP2B1/2 activity in rat hepatic microsomes that can be related to exposure concentration and tissue dose.