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RECORD NUMBER: 125 OF 813

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Main Title

Comparative mesothelioma induction in rats by asbestos and non-asbestos mineral fibers : possible correlation with human exposure risk /

Author

Coffin, D. L. ; Palekar, L. D. ; Cook, P. M. ; Creason, J. P. ;

CORP Author

Northrop Services, Inc., Research Triangle Park, NC.;Health Effects Research Lab., Research Triangle Park, NC.

Publisher

Northrop Services, Inc.,

Year Published

1988

Report Number

PB88250246

Stock Number

PB88-250246

OCLC Number

42725407

Subjects

Asbestos--Toxicology ; Asbestos--Physiological effect

Additional Subjects

Toxicity ; Asbestos ; Hazardous materials ; Attapulgite ; Fibers ; Laboratory animals ; Exposure ; Humans ; Correlations ; Survival ; Neoplasms ; Mesothelioma ; Erionite ; Occupational safety and health

Holdings

Library	Call Number	Additional Info	Location	Last Modified	Checkout Status
ESAD	PB88-250246		Region 10 Library/Seattle,WA	05/14/2012
NTIS	PB88-250246	Some EPA libraries have a fiche copy filed under the call number shown.		07/26/2022

Collation

16 p. : ill. ; 28 cm.

Abstract

Fischer 344 rats were injected intrapleurally with chrysotile and crocidolite asbestos, erionite and attapulgite and observed for their entire lifespan. Detailed analysis of the number per unit mass of the various size categories of the fibers for each mineral species was determined and the dose in terms of actual number of mineral fibers computed. Data for survival time and number of tumors induced suggests that in addition to the length/width factors, an additional property plays a role in fiber potency. Analysis of the available data from the literature, where populations were known to have been exposed to pure mineral fibers, indicates that ranking for human mesothelioma incidence appears congruent with the rat intrapleural data.

Notes

"August 1988." Bibliography: p. 8-9.

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