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Main Title Effect of Phenobarbitol on the Gamma-Glutamyltranspeptidase Activity and the Remodeling of Nodules Induced by the Initiation-Selection Model.
Author Herren-Freund, S. L. ; Pereira, M. A. ;
CORP Author Health Effects Research Lab., Cincinnati, OH.
Year Published 1985
Report Number EPA/600/J-85/162;
Stock Number PB86-107216
Additional Subjects Environmental surveys ; Phenobarbital ; Enzymes ; Toxicology ; Laboratory animals ; Dosage ; Exposure ; Rats ; Mathematical models ; Liver diseases ; Reprints ; Nitrosamine/diethyl ; Transpeptidase/glutamyl ; Cancer
Library Call Number Additional Info Location Last
NTIS  PB86-107216 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 11p
Enzyme-altered foci and nodules have been observed in the liver of rats treated with diethylnitrosamine(DENA) followed by selection with 0.02% 2-acetylaminofluorene (2-AAF) and a partial hepatectomy (PH) (DENA-2AAF-PH treatment). The authors determined the effect of subsequent administration of phenobarbital or of a second dose of DENA on the progression or reversion of these lesions. After the removal of 2-AAF from the diet, one group of rats received no further treatment, another group received subsequent exposure to phenobarbital, a third group received a second dose of DENA, and a fourth group received a second dose of DENA without the partial hepatectomy during the 2-AAF exposure. The rats were sacrificed at various times up to 58 weeks following the 2-AAF exposure. Subsequent exposure to phenobarbital did not alter the tumor incidence in the DENA-2AAF-PH treated rats while the second dose of DENA resulted in an increased incidence of hyperplastic nodules and hepatocellular carcinomas as well as an increase in renal tubular adenomas and carcinomas.