Record Display for the EPA National Library Catalog

RECORD NUMBER: 29 OF 41

Main Title Occupational Pesticide Exposure and Renal Tubular Dysfunction.
Author Mann, Joel B. ; Davies, John E. ; Shane., Robald W. ;
CORP Author National Communicable Disease Center, Atlanta, Ga.
Year Published 1967
Stock Number PB-278 096
Additional Subjects Toxicology ; Pesticides ; Insecticides ; Industrial medicine ; Kidney ; Physiology ; Phosphorus organic compounds ; Cholinesterase ; Enzymes ; Nitrophenols ; Humans ; Exposure ; Toxic substances ; Occupational safety and health ; Parathion ; Metabolites ; Urinalysis ; Reprints
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB-278 096 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 8p
Abstract
An apparent etiologic relationship between occupational exposure to pesticides and renal tubular malfunction was discovered incidentally during the development of a practical surveillance technique for persons occupationally exposed to parathion, an organophosphate type of insecticide. For this surveillance method, grab samples of urine were obtained and analyzed for paranitrophenol, the major urinary metabolite of parathion. Urinary levels of paranitrophenol, expressed in parts per million (ppm), were then independently correlated with observed spray technique and with measurements of red cell cholinesterase. An average urinary level of approximately 4.5 ppm was found to be the level above which red cell cholinesterase became increasingly depressed and which was associated with a 70 per cent absenteeism rate due to pesticide-induced illness. (Portions of this document are not fully legible)