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RECORD NUMBER: 2 OF 8

OLS Field Name OLS Field Data
Main Title Chronic Inhalation Exposure to Rats and Rabbits with Nitromethane and 2-nitropropane (Final Report) with Attachments and Cover Letter Dated 08/10/1989.
CORP Author Huntingdon Research Center, Inc., Baltimore, MD.; Rohm and Haas Co., Philadelphia, PA.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1989
Report Number 86-890001529
Stock Number OTS0520658
Additional Subjects Toxicology ; Health effects ; Nitromethane (75-52-5) ; Subchronic Toxicity ; Mammals ; Rats ; Inhalation ; Chronic Toxicity ; Rabbits ; Toxic substances ; Laboratory animals ; CAS No 75-52-5 ; CAS No 79-46-9
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NTIS  OTS0520658 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 03/10/2010
Collation 239p
Abstract
Groups of 50 male Sprague-Dawley rats and 15 male New Zealand white rabbits were exposed by inhalation for 7 hours/day, 5 days/week for 6 months to nitromethane (exposure concentrations of 100 and 750 ppm) or 2-nitropropane (25 and 200 ppm). Exposure to nitromethane caused reduced body weight gain and slightly depressed hematocrit and hemoglobin levels in high-dose rats, and in rabbits it induced elevated ornithine carbamyl transferase and possibly depressed hemoglobin levels. Some evidence of pulmonary edema and other pulmonary abnormalities were seen at 1 month post-treatment in rabbits of both dose groups. Exposure to 2-nitropropane induced elevated ornithine carbamyl transferase in high-dose rabbits but not rats. Liver weights were elevated in high-dose animals of both species, accompanied by severe neoplastic changes in livers of rats.