| Main Title |
Effect of Coadministration of Phenobarbital Sodium on N-Nitrosodiethylamine-Induced Gamma-Glytamyltransferase-Positive Foci and Hepatocellular Carcinoma in Rats. |
| Author |
Pereira, M. A. ;
Herren-Freund, S. L. ;
Britt, A. L. ;
Khoury, M. M. ;
|
| CORP Author |
Health Effects Research Lab., Cincinnati, OH. ;Cincinnati Univ., OH. Coll. of Medicine. |
| Year Published |
1984 |
| Report Number |
EPA/600/J-84/094; |
| Stock Number |
PB84-245620 |
| Additional Subjects |
Carcinogens ;
Environmental surveys ;
Laboratory animals ;
Rats ;
Liver ;
Neoplasms ;
Nitrogen organic compounds ;
Reprints ;
Phenobarbital ;
GGTase-positive foci ;
Diethylamine/N-nitroso ;
ATPase-deficient foci
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB84-245620 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
7p |
| Abstract |
The effect of concurrent administration of phenobarbital on the hepatocarcinogenicity of N-nitrosodiethylamine (diethylnitrosamine; DENA) in rats was investigated by determination of the incidence of gamma-glutamyltransferase (gamma-glutamyltranspeptidase) (GGT)-positive foci and liver tumors. Male outbred Sprague-Dawley rats received either a weekly oral dose of DENA (0.08 mol/kg), phenobarbital sodium (500 ppm) in their drinking water, or DENA and phenobarbital sodium concurrently. After 16 weeks, only the animals treated concurrently with DENA and phenobarbital sodium had GGT-positive foci (3.65 foci/sq cm). At 30 weeks, the group treated with DENA and phenobarbital sodium exhibited more foci (23.6 foci/sq cm) compared to the group that received only DENA (3.08 foci/sq cm). The average size of foci in both of the DENA-treated groups was the same. The tumors in the group that received DENA plus phenobarbital sodium showed a greater incidence of GGT activity compared to the tumors in the DENA group. Under the conditions of this study the incidence of GGT-positive foci did not predict the incidence of hepatocellular carcinomas. |
