Mice exposed to chlorine dioxide for 30 days at 100 ppm exhibited no significant differences from controls in any of the blood parameters measured. There were no additive or synergistic effects between chlorine dioxide and nitrite based on these same measurements. When A/J (high G6PD) and C57L/J (low G6PD) mice were exposed to various levels of sodium chlorite (0.0, 1.0, 10.0, and 100 ppm) for 30 days in their drinking water, there were a number of blood parameters that varied significantly with respect to treatment. However, with the exception of an increase in hemoglobin for the C57L/J strain at the 1.0 and 10.0 ppm level, all significant changes were associated with the 100 ppm exposure. There were no significant strain versus treatment interactions for any level of chlorite exposure.