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Main Title Investigation of effects of prolonged inhalation of nickle-enriched fly ash in Syrian golden hamsters /
Author Wehner, Alfred P.
CORP Author Battelle Pacific Northwest Labs., Richland, WA.;Health Effects Research Lab., Cincinnati, OH.
Publisher U.S. Environmental Protection Agency, Research and Development, Health Effects Research Laboratory,
Year Published 1981
Report Number EPA/600/1-81/009A; EPA-68-03-2457
Stock Number PB81-152514
Subjects Nickel ; Fly ash ; Lungs--Dust diseases ; Hamsters
Additional Subjects Nickel ; Toxicology ; Fly ash ; Hamsters ; Laboratory animals ; Exposure ; Aerosols ; Inhalation ; Air pollution effects(Animals)
Library Call Number Additional Info Location Last
NTIS  PB81-152514 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 151 pages ; 28 cm
Groups of 102 Male Syrian Golden hamsters were chronically exposed to approx. 70 micrograms/l respirable Nickel Enriched Fly Ash aerosol (high NEFA group), approx. 17 micrograms/l (low NEFA group), or approx. 70 micrograms/l FA 6 hrs/day, 5 days/week for 4, 8, 12, 16 and 20 months. Identical control groups received sham exposures. The NEFA particles of respirable size contained approximately 6% nickel, compared to about 0.3% for FA. Exposure to NEFA had no significant effect on the apparent well being, body weight and life span of the animals although heavy deposits of NEFA in the lungs were found. The lung weights and mean lung volumes of the high NEFA and FA exposed animals were significantly higher and larger, respectively, than for the low NEFA and control groups. There was a 100% incidence of dust deposition (anthracosis) and significantly higher incidence plus severity of interstitial reaction and bronchiolization in the dust-exposed groups than the controls. The severity of lung reactions was significantly lower in the low NEFA group than the high NEFA and FA groups. The results of this study conclude that the addition of nickel to fly ash under these conditions did not significantly (P< 0.05) enhance the pathogenicity (including carcinogenicity) of fly ash in this animal model.
Caption title. "January 1981." "EPA-600/1-81-009a." Microfiche.