Record Display for the EPA National Library Catalog


Main Title Health assessment document for nickel.
Publisher United States Environmental Protection Agency, Office of Health and Environmental Assessment, United States Environmental Protection Agency, Center for Environmental research Information
Year Published 1990
Report Number EPA/600-S8-83-012
OCLC Number 899247171
Subjects Nickel--Physiological effect ; Nickel--Toxicology
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
EJBD ARCHIVE EPA 600-S8-83-012 In Binder Headquarters Library/Washington,DC 04/05/2018
EJBD  EPA 600-S8-83-012 In Binder Headquarters Library/Washington,DC 10/03/2018
Collation 6 pages ; 28 cm
Caption title. At head of title: Project Summary. "July 1987." "EPA/600-S8-83-012."
Contents Notes
The predominate atmospheric forms of nickel are as sulfate, oxides, and complex oxides. Nickel also occurs in ambient and drinking water and soils. Routes of intake for man are inhalation, ingestion, and percutaneous absorption. Pulmonary absorption varies according to chemical and physical form of the compound. While gastrointestinal intake ranges from 300 to 500 [mu]g daily, absorption is only one to ten percent of intake. Percutaneous absorption, usually through contact with nickel alloys in the household, is related to hypersensitivity and skin disorders. In haled nickel compounds lead to highest levels in lung, brain, kidney and liver. Nickel exposure produces chronic dermatological, respiratory, endocrine and cardiovascular effects. Reproductive and developmental effects have been found in animals but not humans. Various nickel compounds have been tested for mutagenicity, demonstrating the ability of nickel compounds to produce genotoxic effects; the translation of these effects into actual mutations is still not clearly understood. There is evidence both in humans and animals for the carcinogenicity of nickel in some forms. Lifetime cancer risks for continuous inhalation exposure at 1 [mu]g nickel/mp3s have been estimated for nickel refinery dust and nickel subsulfide. There is a growing evidence that nickel may be an essential element for humans.