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Main Title Nitrite Induced Iron Deficiency in the Neonatal Rat.
Author Roth, A. C. ; Smith, M. K. ;
CORP Author Health Effects Research Lab., Cincinnati, OH. Toxicology and Microbiology Div.
Publisher c1988
Year Published 1988
Report Number EPA/600/J-88/411;
Stock Number PB90-110099
Additional Subjects Nitrites ; Iron deficiency anemia ; Toxicity ; Rats ; Blood chemical analysis ; Animal physiology ; Growth abnormalities ; Mortality ; Supplements ; Fatty metamorphosis(Liver) ; Spleen ; Milk ; Body weight ; Reprints ; Deficiency diseases ; Drinking water ; Newborn animals ; Water pollution effects(Animals) ; Maternal-fetal exchange
Library Call Number Additional Info Location Last
NTIS  PB90-110099 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 12p
Neonatal rats from dams administered 2 or 3 grams NaNO2/L in the drinking water through gestation and lactation suffered severe microcytic anemia as well as growth retardation and high mortality. Lipemia, fatty liver damage, decreased erythropoiesis of spleen and bone marrow and reduced plasma and tissue iron levels were noted in affected pups. These effects were all consistent with and characteristic of iron deficiency. Experiments presented here were designed to show that the maternally mediated toxicity of nitrite is actually an iron deficiency syndrome in the pups caused by inadequate iron transfer from dam to pup. First it was demonstrated that administration of exogenous iron supplement to pups of treated mothers reversed the anemia and other effects of nitrite toxicity noted both in previous studies and in unsupplemented littermates. It was then shown that mothers of affected pups were themselves anemic and somewhat iron deficient. Finally, severe iron deficiency in pups of nitrite treated mothers was documented. It was shown that these mothers produced milk of reduced iron content. (Copyright (c) 1988 by Academic Press, Inc.)