| Main Title |
Evaluation of Delayed Neurotoxicity and Dose-Response Relationships of Phosphate Esters in the Adult Hen Prepared by Monsanto Company with Cover Letter. |
| CORP Author |
Du Pont de Nemours (E.I.) and Co., Wilmington, DE. DuPont Environmental Remediation Services.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Publisher |
4 Feb 1983 |
| Year Published |
1983 |
| Report Number |
878211730; |
| Stock Number |
OTS-0205858 |
| Additional Subjects |
Toxicity ;
Phosphates ;
Esters ;
Neurotoxins ;
Dose response relationships ;
Alkyls ;
Phenols ;
Histological techniques ;
Tritration ;
Oral intake ;
Dermal absorption ;
Evaluation ;
Laboratory animals ;
Aryl phosphates ;
Phosphoric acid ;
Methylphenyl ester
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS-0205858 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
25p |
| Abstract |
An oral multiple-dose technique in hens was developed to determine the neurotoxic potential of a series of triaryl-, trialkyl- and alkyl-aryl phosphates. This potential was estimated by observation of abnormal behavioral signs and always verified by histological examination. This procedure permits dose tritration of an active material to quantify dose-response relationships. Initial evaluation of a series of phosphates for neurotoxicity yielded 3 active materials: tricresyl-phosphate, cresyl-diphenyl phosphate and o-isopropylphenyl- diphenyl-phosphate. Subsequent titration of active materials demonstrated that their neurotoxic potential differed markedly. |
