Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Therapeutic Ribonucleic Acids in Brain Tumors [electronic resource] /
Author Erdmann, Volker A.
Other Authors
Author Title of a Work
Reifenberger, Guido.
Barciszewski, Jan.
Publisher Springer Berlin Heidelberg,
Year Published 2009
Call Number RC261-271
ISBN 9783642004759
Subjects Medicine. ; Oncology. ; Biochemistry. ; Neurosurgery.
Internet Access
Description Access URL
Collation XVI, 494 p. online resource.
Due to license restrictions, this resource is available to EPA employees and authorized contractors only
Contents Notes
Molecular Biology of Malignant Gliomas -- Molecular Neurooncology and Neoangiogenesis of Malignant Gliomas -- Molecular Therapies for Malignant Gliomas -- Novel Strategies for the Treatment of Brain Cancer -- Gene Therapy for Malignant Glioma -- Immunotherapeutic Approach for Glioma by Alphaviruses as Positive Strand RNA Viruses -- Diagnosis of Brain Tumors Through Global Specific DNA Methylation Analysis -- Molecular Markers of Gliomas -- Microarray and Proteomic Analysis of Gliomas: Target Strategies -- Nanosystems for the Delivery of RNAi -- Interference RNA Intervention in Brain Tumors -- Blood-Brain Barrier Transport for RNAi -- Therapeutic Potential of Small Interfering RNA for Brain Diseases -- RNA Interference-Based Therapies Against Brain Tumors: Potential Clinical Strategies -- MicroRNA: Biogenesis, Regulation, and Role in Primary Brain Tumors -- Treatment of High-Grade Gliomas in Adults -- Treatment of Malignant Gliomas with Antisense Oligonucleotides -- Suppression of EGFR Expression by Antisense RNA and RNAi -- Brain Tumor Therapy with Antisense Oligonucleotides -- Noncoding RNAs in the Development, Function and Pathologies of the Central Nervous System -- The Non-Coding Oncofetal H19 Gene in Brain Tumors. In the past few years nucleic acids technologies have grown into a powerful analytical and also increasingly therapeutic tool. It has been applied not only to the uncovering of gene functions in many organisms, but also to pathogenetic analysis and recently also for the treatment of human diseases. The book discusses in depth the potential of these innovative methods in the broad field of central nervous system and brain tumours particularly. Whereas there is currently no comprehensive overview on potential and challenges of nucleic acids technologies for basic brain tumours and for the clinical management of patients with brain tumours, this book does explicitly cover the many other aspects of the "RNA World" (pathogenic and therapeutic potential of microRNAs, aptamer technology, etc.), too. With this significantly broadened scope as compared to currently existing books it appears to be an urgently needed new publication.