Record Display for the EPA National Library CatalogRECORD NUMBER: 1 OF 7
|Main Title||Electromyographic Examination of Dogs Treated with Ketone Solvents with Cover Letter.|
|CORP Author||Eastman Kodak Co., Rochester, NY.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.|
|Additional Subjects||Electromyographic tests ; Toxicity ; Laboratory animals ; Neuropathy ; Dogs ; Injections ; Ketone solvents ; Methyl ehtyl ketone ; Methyl n-butyl ketone ; Methyl isobutyl ketone ; CAS No 78-93-3 ; CAS No 591-78-6 ; CAS No 108-10-1|
Electromyrographic (EME) examination of dogs administered 300 mg/kg of body weight daily of MiBK, MEK, MCK:MnBK (9:1), MEK:MiBK (9:1) by subcutaneous injection for approximately eleven months did not demonstrate evidence of neurotoxicity. Examination of a group of dogs administered 300 mg/kg of body weight daily of MBK by subcutaneous injection demonstrated EMG changes in two out of three dogs recovering from MBK induced neuropathy.