Record Display for the EPA National Library Catalog


Main Title Central Adrenergic Receptor Changes in the Inherited Noradrenergic Hyperinnervated Mutant Mouse Tottering (Journal Version).
Author Levitt, P. ; Lau, C. ; Pylypiw, A. ; Ross, L. L. ;
CORP Author Medical Coll. of Pennsylvania, Philadelphia.;Health Effects Research Lab., Research Triangle Park, NC.
Publisher c1987
Year Published 1987
Report Number EPA-68-02-4032 ;EPA-68-02-4450; EPA/600/J-87/410;
Stock Number PB89-105563
Additional Subjects Brain ; Adrenergic receptors ; Epilepsy ; Locus coeruleus ; Neurons ; Petit mal epilepsy ; Laboratory animals ; Norepinephrine ; Alpha adrenergic receptors ; Beta adrenergic receptors ; Spinal cord ; Hippocampus ; Cerebellum ; Reprints ; Tottering mice ; Neurologic mutants
Library Call Number Additional Info Location Last
NTIS  PB89-105563 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 6p
Adrenergic receptor binding characteristics were analyzed in the mutant mouse tottering (tg/tg), a single gene locus autosomal recessive mutation causing hyperinnervation by locus coeuruleus neurons of their target regions, which results in epilepsy. Instead of the expected down-regulation of receptors due to the hyperinnervation, both 3H-prazosin (alpha 1-receptor) and 125I-iodopindolol (beta-receptor) binding were normal in the tg/tg hippocampus, spinal cord and slightly increased in the cerebellum. The lack of postsynaptic receptor modulation in the target cells, combined with increased levels of norepinephrine due to the aberrant axon growth, may be critical factors in the expression of the abnormal spike-wave absence seizures in the tg/tg mouse. (Copyright (c) 1987 Elsevier Science Publishers B.V.)