Record Display for the EPA National Library Catalog


Main Title Assessment of Chemically-Induced Alterations in Brain Development Using Assays of Neuron- and Glia-Localized Proteins.
Author O'Callaghan, J. P. ; Miller, D. B. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Publisher c1989
Year Published 1989
Report Number EPA/600/J-89/438;
Stock Number PB91-109306
Additional Subjects Toxicology ; Brain ; Nerve cells ; Reprints ; Ontogeny ; Neuroglia ; Encephalitogenic basic proteins ; Glial fibrillary acidic protein ; Organotin compounds
Library Call Number Additional Info Location Last
NTIS  PB91-109306 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 16p
Chemical intervention during prenatal or postnatal ontogeny can result in complex biochemical, morphological and behavioral alterations in brain development. As has been shown at the conference, the knowledge of specific actions of a given drug/chemical in the adult can serve as a guide for choosing processes affected by the same compound administered during development. Commonly, however, the neuronal or glial substrates for chemical action in the developing brain are not known and cannot be easily predicted on the basis of effects observed in the mature animal. Indeed, there are a multitude of structurally dissimilar compounds that affect diverse and unpredictable targets in the developing brain. The focus of the review is to present an approach for detecting and characterizing chemically-altered brain development that can be used regardless of the information available on the chemical in question. (Copyright (c) 1989 by Intox Press, Inc.)