Record Display for the EPA National Library Catalog
RECORD NUMBER: 510 OF 1140| Main Title | Evaluation of the potential carcinogenicity of streptozotocin (18883-66-4) / | |||||||||||
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| CORP Author | Environmental Monitoring and Services, Inc., Washington, DC. ;Syracuse Research Corp., NY.;Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment. | |||||||||||
| Publisher | U.S. Environmental Protection Agency, Office of Emergency and Remedial Response ; | |||||||||||
| Year Published | 1988 | |||||||||||
| Report Number | EPA/600/8-91/180; EPA-68-03-3112; EPA-68-03-3182; OHEA-C-073-175 | |||||||||||
| Stock Number | PB93-201275 | |||||||||||
| Subjects | Streptozotocin--Carcinogenicity | |||||||||||
| Additional Subjects | Streptozocin ; Antibiotics ; Toxicity ; Risk assessment ; Public health ; Exposure ; Hazardous materials ; Neoplasms ; Tolerances(Physiology) ; Carcinogenicity ; Dose-response relationships ; CAS: 18883-66-4 | |||||||||||
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| Collation | 19 pages ; 28 cm | |||||||||||
| Abstract | Streptozotocin (also streptozocin) is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment. Evidence on potential carcinogenicity from animal studies is 'Sufficient', and the evidence from human studies is 'No Data'. The potency factor (F) for streptozotocin is estimated to be 109 (mg/kg/day)-1, placing it in potency group 1 according to the CAG's methodology for evaluating potential carcinogens. Combining the weight-of-evidence group and the potency group, streptozotocin is assigned a 'HIGH' hazard ranking. |
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| Notes | Cover title. "June 1988." Includes bibliographical references. Microfiche. |