| Main Title |
Comparison of Enhancement of GGTase-Positive Foci and Induction of Ornithine Decarboxylase in Rat Liver by Barbiturates. |
| Author |
Pereira, Michael A. ;
Savage, Jr.,, Russell E. ;
Herren, Sydna L. ;
Guion, Charles W. ;
|
| CORP Author |
Health Effects Research Lab., Cincinnati, OH. |
| Year Published |
1981 |
| Report Number |
EPA-600/J-82-271; |
| Stock Number |
PB83-157586 |
| Additional Subjects |
Barbiturates ;
Rats ;
Liver ;
Malignant neoplasms ;
Comparison ;
Reprints ;
Cancer ;
GGTase ;
Ornithine decarboxylase ;
Carcinogenesis
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB83-157586 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
6p |
| Abstract |
The induction of ornithine decarboxylase (ODC) by barbiturates and the ability of barbiturates to enhance neoplastic progression of chemically initiated cancer was examined in rat liver. All seven barbiturates induced ODC with barbital (7.7 fold increase) and phenobarbital (5.7 fold increase) demonstrating the most potent activity. Maximum induction of ODC by phenobarbital was obtained in 18 h. Barbital (500-5000 p.p.m.) and phenobarbital (500 p.p.m.) administered in the drinking water enhanced the appearnace of diethylnitrosamine (DENA)-initiated gamma-glutamyltranspeptidase (GGTase)-positive foci. Amobarbital, hexabarbital and pentabarbital did not enhance the appearance of GGTase-positive foci. In the absence of previous initiation by DENA, the enhancing regimen of the barbiturates did not cause the appearance of GGTase-positive foci. Barbiturates induced ODC activity in rat liver and enhanced the incidence of DENA initiated GGTase-positive foci. |
