| Main Title |
Acute and Subchronic Inhalation Exposures of Hamsters to Nickel-Enriched Fly Ash. |
| Author |
Wehner, Alfred P. ;
Moss, Owen R. ;
Milliman, Edward M. ;
Dagle, Gerald E. ;
Schirmer, Roger E. ;
|
| CORP Author |
Battelle Pacific Northwest Labs., Richland, WA. Biology Dept.;Health Effects Research Lab., Cincinnati, OH. |
| Year Published |
1981 |
| Report Number |
EPA-68-03-2457; EPA-600/J-79-125; |
| Stock Number |
PB81-201147 |
| Additional Subjects |
Fly ash ;
Toxicology ;
Nickel ;
Respiration ;
Exposure ;
Hamsters ;
Laboratory animals ;
Concentration(Composition) ;
Aerosols ;
Lung ;
Reprints ;
Air pollution effects(Animals) ;
Toxic substances ;
NTISEPAORD
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB81-201147 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
18p |
| Abstract |
One 6-hr inhalation exposure of hamsters to Ni-enriched fly ash (NEFA) aerosol (respirable aerosol concentration approx. 200 micrograms/liter) deposited about 80 micrograms in the deep lung, of which 75 micrograms was still present 30 days postexposure. The animals tolerated the exposure well during the 30-day postexposure observation period. Two-month exposures of hamsters to NEFA or fly ash (FA) aerosols (approx. 185 micrograms/liter) resulted in a deep lung burden of about 5.7 mg, dark discoloration of lungs, heavily dust-laden macrophages, and significantly higher lung weights than in controls, but only minimal inflammatory reaction and no deaths. There was no difference between NEFA and FA effects. The NEFA contained 9% Ni; FA contained 0.03% Ni. The results of this study indicate low acute and subchronic toxicity and slow lung clearance of NEFA and FA. |
