| Main Title |
An SAB report : development of the acute reference exposure. / |
| Other Authors |
|
| CORP Author |
Environmental Protection Agency, Washington, DC. Science Advisory Board. |
| Publisher |
United States Environmental Protection Agency, Science Advisory Board, |
| Year Published |
1998 |
| Report Number |
EPA-SAB-EHC-98-006; EPA-SAB-EHC-99-005 |
| Stock Number |
PB99-124398 |
| OCLC Number |
41113965 |
| Additional Subjects |
Acute exposure ;
Inhalation ;
Hazardous materials ;
Dose-response relationships ;
Chemical compounds ;
Health hazards ;
Toxicity ;
Exposure ;
Human populations ;
Dose rates ;
Benchmarks ;
Regression analysis ;
Categorical regression ;
NOAEL(No-Observable- Adverse-Effect)
|
| Internet Access |
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| EHAD |
EPA SAB-EHC-98-006 |
|
Region 1 Library/Boston,MA |
01/04/2016 |
| EJAD |
EPA SAB/EHC-99-005 |
|
Region 3 Library/Philadelphia, PA |
08/27/1999 |
| EJBD ARCHIVE |
EPA-SAB-EHC-98-005 |
|
Headquarters Library/Washington,DC |
05/16/2016 |
| EJBD |
EPA-SAB-EHC-99-005 |
|
Headquarters Library/Washington,DC |
07/07/2016 |
| ELBD |
EPA SAB-EHC-99-005 |
|
AWBERC Library/Cincinnati,OH |
09/08/2000 |
| ESAD |
SAB-EHC-99-005 |
|
Region 10 Library/Seattle,WA |
03/23/2010 |
| NTIS |
PB99-124398 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
24 pages ; 28 cm |
| Abstract |
The Environmental Health Committee (EHC) reviewed the EPA's methodology document, 'Methods for Exposure-Response Analysis for Acute Inhalation Exposure to Chemicals, Development of the Acute Reference Exposure'. the EHC commends the Agency for developing methodology to derive Acute Reference Exposures (ARE), a chemical-specific acute exposure (with an uncertainty spanning an order of magnitude) that is not likely to cause adverse effects in a human population. Overall, approaches for the NOAEL and the benchmark concentration and for duration extrapolation were found to be clear and appropriate. However, the EHC does not support the use of the categorical regression (CatReg) approach for developing an ARE based on the lack of biological-plausibility for the methodology, the lack of justification for the scaling factor to accommodate within-group correlations and group size and the unrealiability of the types of confidence limits used. |
| Notes |
Cover title. "EPA-SAB-EHC-99-005." "November 23, 1998." Includes bibliographical references. |
