Record Display for the EPA National Library Catalog

RECORD NUMBER: 151 OF 286

Main Title L5178y Tk+/- Mouse Lymphoma Mutagenesis Assay with Confirmation Test Article Oleylamine. Final Report with Cover Letter dated 10/03/1989.
CORP Author Chemical Manufacturers Association, Washington, DC.; Microbiological Associates, Bethesda, MD.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1989
Report Number FYI-AX-1089-0391
Stock Number OTS0000391-1
Additional Subjects Toxicology ; Health effects ; Oleylamine ; Genotoxicity ; Gene mutations ; Mammals ; Mice ; In vitro ; CAS No 112-90-3
Holdings
Library Call Number Additional Info Location Last
Modified		 Checkout
Status
NTIS  OTS0000391-1 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 69p
Abstract
The ability of oleylamine to induce specific locus mutations at the TK locus in cultured L5178Y mouse lymphoma cells (Mouse Lymphoma Mutagenesis Assay) was evaluated both in the presence and absence of metabolic activation from Aroclor-induced rat liver S9 fraction. Based on preliminary toxicity tests, 10 non-activated cultures treated with 0.13, 0.18, 0.24, 0.32, 0.42, 0.56, 0.75, 1.0, 1.3, or 1.8 nl/ml produced a range of 3-110% total growth. Eight activated cultures treated with 1.3, 1.8, 2.4, 3.2, 4.2, 5.6, 7.5, or 10 nl/ml produced a range of 6-106% total growth. Mutant frequencies in all treated cultures were less than 2 times that of the solvent (DMSO, acetone) controls, either with or without metabolic activation.