Record Display for the EPA National Library Catalog

RECORD NUMBER: 23 OF 81

Main Title Evaluation of selected pesticides as chemical mutagens 'in vitro' and 'in vivo' studies /
Author Simmon, Vincent F.
Other Authors
Author Title of a Work
Mitchell, Ann D.
Jorgenson, Ted A.
CORP Author Stanford Research Institute, Menlo Park, Calif.;Health Effects Research Lab., Research Triangle Park, N.C.
Publisher N.T.I.S.,
Year Published 1977
Report Number EPA/600/1-77/028; SRI-LSU-3493; EPA-68-01-2458
Stock Number PB 268 647
OCLC Number 07038421
Subjects Chemical mutagenesis ; Pesticides--Testing ; Mutagenicity testing ; Mutagens ; Mutagens--Testing
Additional Subjects Pesticides ; Mutagens ; Toxicology ; In vivo analysis ; In vitro analysis ; Toxicity ; Genetics ; Mutations ; Deoxyribonucleic acids ; Biosynthesis ; Bioassay ; Mice ; Laboratory animals ; Tissue culture ; Microorganisms ; Dosage ; Mutagenesis
Internet Access
Description Access URL
https://nepis.epa.gov/Exe/ZyPDF.cgi?Dockey=9100SHSP.PDF
Holdings
Library Call Number Additional Info Location Last
Modified		 Checkout
Status
EHBD  EPA-600/1-77-028 CEMM/ACESD Library/Narragansett,RI 03/09/2007
EJED  EPA-600/1-77-028 OCSPP Chemical Library/Washington,DC 07/26/1991
EKBD  EPA-600/1-77-028 Research Triangle Park Library/RTP, NC 02/06/2012
EKCD  EPA-600/1-77-028 CEMM/GEMMD Library/Gulf Breeze,FL 05/29/2018
ELBD ARCHIVE EPA 600-1-77-028 Received from HQ AWBERC Library/Cincinnati,OH 10/04/2023 DISPERSAL
NTIS  PB-268 647 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation ix, 238 pages : illustrations ; 28 cm
Abstract
Twenty pesticides were studied for mutagenic activity by several in vitro and in vivo test procedures. The pesticides reviewed were: monocrotophos, bromacil, cacodylic acid, captan, chlorpyrifos, dinoseb, DSMA, fenthion, folpet, azinphos-methyl, malathion, methomyl, monuron, MSMA, parathion, parathion-methyl, quintozene (PCNB), phorate, simazine, and trifluralin. Ten of the twenty compounds were evaluated in vivo by the mouse dominant lethal test. All twenty compounds were tested in vitro. None of the ten compounds tested in the mouse produced a dominant lethal response. Ten of the twenty compounds were mutagenic in one or more in vitro assays. Two were mutagenic in all of the in vitro assays: captan and folpet.
Notes
Prepared for the Health Effects Research Lab, Research Triangle Park, N.C., by Stanford Research Institute, Menlo Park, Ca. Contract number 68-01-2458. EPA-600/1-77-028.