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Main Title Comparison of Subchronic Neurotoxicity of 2-Hydroxyethyl Acrylate and Acrylamide in Rats.
Author Moser, V. C. ; Anthony, D. C. ; Sette, W. F. ; MacPhail, R. C. ;
CORP Author ManTech Environmental Technology, Inc., Research Triangle Park, NC. ;Duke Univ. Medical Center, Durham, NC. Dept. of Pathology.;Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div.
Publisher c1992
Year Published 1992
Report Number EPA-68-02-4450; EPA/600/J-92/188;
Stock Number PB92-188945
Additional Subjects Toxicity ; Nervous system ; Acrylamides ; Muscles ; Dose-response relationships ; Body weight ; Axons ; Comparisons ; Brain ; Spinal cord ; Peripheral nerves ; Reprints ; 2-Hydroxyethylacrylates ; Functional observational battery
Library Call Number Additional Info Location Last
NTIS  PB92-188945 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 12p
The comparative neurotoxicity of subchronic exposure to 2-hydroxyethyl acrylate (HEA) and acrylamide (ACR) was evaluated using a functional observational battery (FOB) and neuropathology. Three dose levels of each compound (HEA: 3, 20, 60 mg/kg; ACR: 1, 4, 12 mg/kg) were administered intraperitoneally to male and female Long-Evans rats (n = 10/sex/dose level), 5 days/week for 13 weeks. Two vehicle control groups were also included. There were clear differences between the effects of HEA and ACR. ACR produced time- and dose-related changes in FOB measures of muscle tone and equilibrium, and produced axonal degeneration in peripheral nerves and within long tracts of the spinal cord. HEA exposure was also associated with changes in muscular function on FOB testing, but the magnitude of the effects was not as great as with ACR and not dose related.