Record Display for the EPA National Library Catalog


Main Title Distribution of Cardiac Output during Diurnal Changes of Activity in Rats.
Author Delp, M. D. ; Manning, R. O. ; Bruckner, J. V. ; Armstrong, R. B. ;
CORP Author Georgia Univ., Athens. Dept. of Pharmacology and Toxicology.;Health Effects Research Lab., Research Triangle Park, NC.;National Institutes of Health, Bethesda, MD.
Publisher c1991
Year Published 1991
Report Number NIH-AM-37098; EPA/600/J-93/109;
Stock Number PB93-180982
Additional Subjects Heart function tests ; Diurnal variations ; Rats ; Motor activity ; Body temperature ; Muscles ; Heart ; Brain ; Lung ; Gastrointestinal system ; Skin ; Bones ; Reproductive system ; Reprints ;
Library Call Number Additional Info Location Last
NTIS  PB93-180982 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 10p
Rat locomotor and feeding behavior varies on a diurnal basis: at night the animals actively forage and eat, whereas during the day they are more inactive and somnolent. At night, cardiac output is higher, presumably for enhanced perfusion of the active muscles to support increased metabolism and for enhanced perfusion of the digestive organs to support increased digestion and nutrient absorption. Conversely, it is hypothesized that during the daytime, blood flow to these two tissues is relatively low. The purpose of this study was to test these hypotheses by measuring cardiac output and the distribution of cardiac output in rats at various times in the diurnal cycle (8:00 A.M., 4:00 P.M., and 8:00 P.M.). (Copyright (c) 1991 the American Physiological Society.)