| Main Title |
Position-Specific Induction of Benzo(a)pyrene Metabolism by 3-Methylcholanthrene and Phenobarbital in Mullet ('Mugil cephalus'), a Marine Fish. |
| Author |
Schoor, W. P. ;
Srivastava, M. ;
|
| CORP Author |
Environmental Research Lab., Gulf Breeze, FL. ;Auburn Univ., AL. Dept. of Ch emistry. |
| Year Published |
1984 |
| Report Number |
EPA/600/J-84/079; |
| Stock Number |
PB84-243823 |
| Additional Subjects |
Water pollution ;
Metabolism ;
Fishes ;
Liver ;
Oxidation ;
Comparison ;
Laboratory animals ;
Reprints ;
Water pollution effects(Animals) ;
Benzo(A)pyrene ;
Mullet ;
Benzopyrenes ;
Mugil cephalus ;
Cholanthrene/methyl ;
Phenobarbital
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB84-243823 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
9p |
| Abstract |
Mullet (Mugil cephalus), a marine fish, were treated with 3-methylcholanthrene and phenobarbital by intraperitoneal injection, and the effects on the metabolism of benzo(a)pyrene by isolated liver microsomes were evaluated. The most significant effect found in treated fish was an increase in the oxidation of benzo(a)pyrene at the bay region. A position-specific increase which was not reflected in an increase in the total activity. Comparison of metabolite patterns of the dihydrodiols of benzo(a)pyrene in the presence and absence of trichloropropene oxide showed the predicted inhibitions were observed in control as well as treated animals. No significant differences in metabolite patterns were found between the 3-methylcholanthrene- and phenobarbital-treated fish in either presence or absence of trichloropropene oxide. Comparison is made to published data on similar position- specific effects observed in rats. |
