The frequency of pollution caused fish kills appears to be increasing and certainly the awareness of the public to these incidents is prevalent. The Water Quality Office, Environmental Protection Agency and the Ohio Cooperative Fishery Unit, Ohio State University, cosponsored a seminar dealing with fish kill investigations. In this seminar an attempt was made to bring together the diciplines that may be involved in a fish kill and relate to each other the why, what, where and when of their particular chore. The program is arranged into related subject phases such as administrative, legal, analytical, damage evaluation, and natural versus pollution caused fish kills. Finally, case histories which called for the best abilities and facilities available are presented as examples of the need for a well planned multi-disciplined approach.